• ADHD symptoms as risk factor for PTSD in inpatients treated for alcohol use disorder 

      Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-31)
      Attention deficit hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) are more common in alcohol use disorder (AUD) patients than in the general population. Still, there is a lack of knowledge about the relationship between the two conditions in these patients. The main objective of this study was to examine the prevalence of ADHD symptoms, and the relationship between ADHD ...
    • Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out 

      Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-19)
      <i>Background</i>: Patients with alcohol use disorders (AUD) vary significantly in many clinically important characteristics making them a heterogenous group. AUD patients with comorbid antisocial personality disorder (ASPD) form an important sub-group, and studies indicate that these patients may have poorer treatment outcomes. Therefore, we aimed to investigate the characteristics of AUD inpatients ...
    • Association between cannabis use and physical health problems in Norwegian adolescents: a cross-sectional study from the youth survey Ungdata 

      Mæland, Ragnhild; Lien, Lars; Leonhardt, Marja (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-06)
      Background - Cannabis use is increasing among young Norwegians and several studies show a high incidence of common physical health problems. An association has previously been found between cannabis use and mental health problems. Since physical and mental health problems often co-occur, the aim of this study is to explore the relationship between cannabis use and physical health problems.<p> <p>Methods ...
    • The Association Between Regular Physical Activity and Depressive Symptoms Among Patients in Treatment of Alcohol and Substance Use Disorders 

      Berger, Endre; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background: Alcohol and other substance use disorders and major depression often co-occur. A sedentary lifestyle is related to major depression and even moderate exercise may prevent and contribute to the treatment of depression. Studies have found an effect of physical activity on depression in alcohol and other substance use disorder patients even in clinical settings.<p> <p>Aim: To investigate ...
    • Circulating cytokine levels in the treatment of comorbid anxiety disorders 

      Johnson, Sverre Urnes; Hoffart, Asle; Tilden, Terje; Toft, Helge Prytz; Neupane, Sudan; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-28)
      Psychotherapy research aims to investigate predictors and moderators of treatment outcome, but there are few consistent findings. This study aimed to investigate cytokines in patients undergoing treatment for anxiety disorders and whether the level of cytokines moderated the treatment outcome. Thirty-seven patients with comorbid and treatment-resistant anxiety disorders were investigated using ...
    • Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs 

      Toft, Helge Prytz; Lien, Lars; Neupane, Sudan Prasad; Abebe, Dawit Shawel; Tilden, Terje; Wampold, Bruce E.; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
      <p><i>Objective - </i>Cross-sectional data show elevated levels of circulating cytokines in psychiatric patients. The literature is divided concerning anti-inflammatory drugs’ ability to relieve symptoms, questioning a causal link between inflammatory pathways and psychiatric conditions. We hypothesised that the development of circulating cytokine levels is related to mental distress, and that this ...
    • The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment 

      Toft, Helge Prytz; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Tilden, Terje; Wampold, Bruce E.; Lien, Lars (Journal article; Peer reviewed, 2018-04-10)
      <b>Background</b><br> Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol ...
    • Effects of age and gender on the relationship between alcohol use disorder and somatic diseases: a national register study in Norway 

      Abebe, Dawit Shawel; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)
      Objective - This study aimed to examine how age and gender moderate the associations between alcohol use disorders (AUD) and several somatic diseases. <p> <p>Design and setting - We performed a retrospective, register-based cohort study with 6-year follow-up of patients with AUD and the general population. Data were acquired from the Norwegian Patient Registry. Cox regressions were used to estimate ...
    • Factors associated with the level of prolactin in patients under remission from Alcohol Use Disorder: A gender perspective 

      Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-07)
      Background: Prolactin mirrors the dopaminergic activity in the brain which is key to understanding alcohol use disorders (AUD). Still, patients with AUD are a heterogenous group and there seem to be gender differences in the relationship between alcohol use and the level of prolactin. In this study, we examined gender-wise relationship of alcohol use trait- and state-related factors with the level ...
    • Geografisk variasjon i vaksnes bruk av avtalespesialistar og DPS i psykisk helsevern 

      Holsen, Maria; Lien, Lars; Solbakken, Ole Andre; Holman, Per Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
      Background: Equitable mental healthcare regardless of area of residence is a political aim in Norway. The purpose of this study is to evaluate geographical variation in private practitioner coverage and explore differences between private practitioners with public reimbursement and local community mental health centers (CMHCs) in terms of diagnoses and scope of outpatient treatment, with a focus on ...
    • Geographic variation in the utilisation of specialist healthcare for patients with severe mental illness in Norway: a population‑based registry study 

      Bedane, Haji Kedir; Lien, Lars; Holsen, Maria; Bale, Marte; Osvoll, Knut Ivar; Holman, Per Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-27)
      Purpose - The aim of this study is to measure geographic variations in mental healthcare service utilisation among patients with severe mental illness in Norway.<p> <p>Method - We analysed data from the Norwegian patient registry for 2014–2018 for patients with severe mental illness. The outcomes measured in this study were: outpatient contact, admission, bed days and total contact rates. Total ...
    • High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders 

      Neupane, Sudan Prasad; Lien, Lars; Martinez, Priscilla; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Hestad, Knut; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-03)
      <p><i>Aims - </i>As major depression (MD) is often comorbid with alcohol‐use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)‐6, IL‐10, tumor necrosis factor (TNF), and interferon (IFN)‐γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. <p><i>Methods - </i>A ...
    • History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Toft, Helge Prytz; Lien, Lars; Bolstad, Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)
      Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ...
    • Incidence of SARS-CoV-2 and all-cause mortality in persons with co-occurring substance use disorder and mental illness during the pandemic: a Norwegian cohort study 

      Leonhardt, Marja; Bramness, Jørgen Gustav; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-28)
      Purpose - Most people were affected by the COVID-19 pandemic. Persons with co-occurring substance use disorder (SUD) and mental illness (MI) are already a marginalized group, with above average mortality. Thus, the study aim was to investigate SARS-CoV-2 incidence and mortality among persons with SUD/MI during the first two years of the pandemic.<p> <p>Methods - This historical cohort study merged ...
    • Inflammatory cytokines in alcohol use disorder patients are lower in smokers and users of smokeless tobacco 

      Bolstad, Ingeborg; Lien, Lars; Moe, Jenny Skumsnes; Pandey, Susmita; Toft, Helge; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background - Smoking and alcohol use often co-occur, and the use of nicotine-containing products is particularly common among persons with alcohol use disorder (AUD). Recent evidence shows that chronic alcohol use leads to inflammation through increased gut permeability and dysregulated cytokine levels. While cigarette smoking also has detrimental health effects, nicotine has immune dampening effects ...
    • Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Walby, Fredrik A; Myhre, Martin Øverlien; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      Background: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) ...
    • Levels of Peripheral Circulating IL-6 and IL-10 Decrease Over Time Despite High Depression Burden in PTSD Patients 

      Bramness, Jørgen Gustav; Lien, Lars; Toft, Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-05)
      Background: Patients with combined depression symptoms and post-traumatic stress disorder (PTSD) often exhibit high levels of circulating inflammatory biomarkers as either a cause or consequence of their disease. We aimed to investigate how cytokines and depression symptoms develop with one-year follow-up and compare them with non-PTSD patients.<p> <p>Methods: The study had a longitudinal design ...
    • Longitudinal determinants of insomnia among patients with alcohol use disorder 

      Bolstad, Ingeborg; Toft, Helge; Lien, Lars; Moe, Jenny Skumsnes; Rolland, Benjamin; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Insomnia is common among patients with AUD and can impair quality of life and cognitive functioning, as well as cause psycho-social problems and increased risk of relapse. Nonetheless, determinants of insomnia in patients with AUD have scarcely been studied. We aimed to examine prevalence and development of self-perceived insomnia among inpatients in treatment for AUD, and to examine factors in ...
    • Norwegian Cross-Cultural Adaptation of the Social and Communities Opportunities Profile-Mini for Persons with Concurrent Mental Health and Substance Use Disorders. 

      Leonhardt, Marja; Kyrdalen, Ellen; Holstad, Atle; Solbakken, Heidi Hurlen; Chiu, Marcus YL; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)
      Persons with concurrent mental health and substance use disorders often do not participate actively in society and remain marginalized. The promotion of social inclusion is important for the care of persons with concurrent disorders. To measure social inclusion, the Social and Communities Opportunities Profile (SCOPE) was developed, followed by its mini version for English-speaking people in Singapore. ...
    • Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment 

      Toft, Helge; Bramness, Jørgen Gustav; Tilden, Terje; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-27)
      <i>Objective</i>: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient ...